Twenty One Pilots are an American musical duo from Columbus, Ohio. Initially a band, the group was formed in 2009 by lead vocalist Tyler Joseph along with Nick Thomas and Chris Salih, who both left in 2011. Since their departure, the line-up has consisted of Joseph and drummer Josh Dun. The duo is best known for their singles "Stressed Out", "Ride", and "Heathens", which achieved commercial success between 2015 and 2016. The duo received a Grammy Award for Best Pop Duo/Group Performance at the 59th Annual Grammy Awards for "Stressed Out".

Starting out, the band independently released two albums, Twenty One Pilots (2009) and Regional at Best (2011), before being signed by record label Fueled by Ramen in 2012. Their label debut Vessel (2013) became the second album in history on which every track received at least a gold certification, making Twenty One Pilots the first and only band to see every song on two albums earn gold or platinum awards.

The duo achieved breakthrough success with their fourth album, Blurryface (2015), which produced the hit singles "Stressed Out" and "Ride" and became the first album on which every track received at least a gold certification from the Recording Industry Association of America. The release of "Heathens" also made the group the first alternative artist in history to have two concurrent top five singles in the Billboard Hot 100 and the third rock act in history to have two singles simultaneously chart in the top five of the Billboard Hot 100, joining the Beatles and Elvis Presley.

The duo released three more studio albums, Trench (2018), Scaled and Icy (2021), and Clancy (2024). They have also garnered ten number-one songs on the Alternative Songs chart.