The Gregory Brothers are an American musical quartet, specializing in comedy music and auto-tuning recorded speech through their YouTube channel Schmoyoho (). After the success of their songs "Chrissy Wake Up" and "It's Corn" in the summer of 2022, NPR reported that they "are responsible for some of the biggest viral songs of the past decade."

Their musical viral video the "Winning" song, part of their Songify the News series (formerly known as Auto-Tune the News), won a 2012 Comedy Award, and their "Bed Intruder Song" received over 141 million YouTube views and entered the Billboard Hot 100. Their releases, "Who's It Gonna Be?" with Weird Al Yankovic and "The Last Fight" with Joseph Gordon-Levitt, parodied the two US presidential debates of 2020.

The three Gregory brothers – drummer/keyboardist Michael, guitarist/bassist Andrew Rose and keyboardist Evan – originally from Radford, Virginia, moved to Brooklyn, New York, in the mid-2000s and met guitarist/bassist Sarah Fullen (who married Evan in 2009) in the local music scene. The band was formed in 2007, with all four members providing vocals, often accompanying "songified" individuals.

After 10 years of activity, having earned the most views by songifying the likes of Antoine Dodson, Charlie Sheen, Paul Vasquez and Daymon Patterson, their Schmoyoho channel reached three million subscribers in March 2017. In commemoration, the Gregory Brothers released a "mega-mashup" of their work, in which they outlined their main goal of eliciting "the maximum amount of happiness for the maximum amount of time".