The Dessoff Choirs is an independent chorus based in New York City. Margarete Dessoff established the organization in 1930 as the union of two choirs she directed, the Adesdi chorus and the A Cappella Singers, whence the plural Choirs. Today, the plural connotes Dessoff's various ensembles, which range from the large Dessoff Symphonic Choir, which appears with major orchestras, to the Dessoff Chamber Choir, which performs in more intimate settings.

The performance of new, unusual, or rarely heard works is a central facet of Dessoff's mission. Under Dessoff's baton, the Dessoff Choirs gave many premieres, including the American premiere of Arnold Schoenberg's Friede auf Erden, the first American performance of Orazio Vecchi's L'Amfiparnaso, and the New York premiere of Bach's cantata Christ lag in Todes Banden. Dessoff's second conductor, Paul Boepple, continued to champion early music, and when he retired after 32 years as musical director, early music had seen its modern renaissance in which Dessoff had played a significant role. In 1951, the Dessoff Choirs performed with the New York Wind Ensemble at a special Peabody Mason Concert series commemorating the Bi-Millennial year in Paris. During Boepple's tenure, the Choirs released 13 recordings, and his editions were published by Theodore Presser as the Dessoff Choir Series.