Sérgio Santos Mendes (Brazilian Portuguese: [ˈsɛʁʒju ˈsɐ̃tuz ˈmẽdʒis]; born February 11, 1941) is a Brazilian musician. His career took off with worldwide hits by his band Brasil '66. He has over 55 releases and is known for playing bossa nova, often crossed with funk. He was nominated for an Oscar for Best Original Song in 2012 as co-writer of the song "Real in Rio" from the animated film Rio.

Mendes, a Brazilian musician, is primarily known in the United States, where his albums were recorded and where most of his touring took place.

Mendes is married to Gracinha Leporace, who has performed with him since the early 1970s. Mendes has collaborated with many artists through the years, including the Black Eyed Peas, with whom he re-recorded in 2006 a version of his breakthrough hit "Mas que Nada".