Run-DMC (also formatted Run-D.M.C., RUN DMC, or some combination thereof) was an American hip hop group from Hollis, Queens New York City, formed in 1983 by Joseph Simmons, Darryl McDaniels, and Jason Mizell. Run-DMC is regarded as one of the most influential acts in the history of hip hop culture and especially one of the most famous hip hop acts of the 1980s. Along with Beastie Boys, LL Cool J, DJ Jazzy Jeff & the Fresh Prince, and Public Enemy, the group pioneered new-school hip hop music and helped usher in the golden age of hip hop. The group was among the first to highlight the importance of the MC and DJ relationship.

With the release of Run-D.M.C. (1984), Run-DMC became the first hip hop group to achieve a Gold record. Run-D.M.C. was followed with the certified Platinum record King of Rock (1985), making Run-DMC the first hip hop group to go platinum. Raising Hell (1986) became the first multi-platinum hip hop record. Run-DMC's cover of "Walk This Way", featuring the group Aerosmith, charted higher on the Billboard Hot 100 than Aerosmith's original version, peaking at number four. It became one of the best-known songs in both hip hop and rock. Run-DMC was the first hip hop act to have their music videos broadcast on MTV, appear on American Bandstand, be on the cover of Rolling Stone, perform at Live Aid, and be nominated for a Grammy Award.

In 2004, Rolling Stone ranked Run-DMC at number 48 in its list of the 100 Greatest Artists of All Time. In 2007, they were named The Greatest Hip Hop Group of All Time by MTV and Greatest Hip Hop Artist of All Time by VH1. In 2009, Run-DMC became the second hip hop group (after Grandmaster Flash & the Furious Five, 2007) to be inducted into the Rock and Roll Hall of Fame. In 2016, the group received a Grammy Lifetime Achievement Award. In 2018, Raising Hell was inducted into the National Recording Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".