The Plastic Ono Band was a rock band formed by John Lennon and Yoko Ono in 1969 for their collaborative and solo projects based on their 1968 Fluxus conceptual art project of the same name.

Lennon and Ono began a personal and artistic relationship in 1968, collaborating on several experimental releases. After their marriage in 1969, they decided their future endeavours would be credited to the Plastic Ono Band. The band featured a rotating line-up of musicians including Eric Clapton, Klaus Voormann, Alan White, Billy Preston, Jim Keltner, Keith Moon, Delaney & Bonnie and Friends, and Lennon's former Beatles bandmates George Harrison and Ringo Starr. After Lennon and Ono moved to New York in 1971, they collaborated with Elephant's Memory under the name "Plastic Ono Elephant's Memory Band". Lennon's collaborations continued under similar names until 1974.

From 2009 to 2015, Ono and her son Sean Lennon led a new incarnation of the group, the Yoko Ono Plastic Ono Band.