Nanci Caroline Griffith (July 6, 1953 – August 13, 2021) was an American singer, guitarist, and songwriter. She often appeared on the PBS music program Austin City Limits starting in 1985 (season 10). In 1994 she won a Grammy Award for the album Other Voices, Other Rooms.

Griffith toured with various other artists including Buddy Holly's band, the Crickets; John Prine, Iris DeMent, Suzy Bogguss, Judy Collins, and The Everly Brothers. Griffith recorded duets with many artists, among them Emmylou Harris, Mary Black, Prine, Don McLean, Jimmy Buffett, Dolores Keane, Willie Nelson, Adam Duritz (singer of Counting Crows), the Chieftains, John Stewart, and Darius Rucker. Griffith referred to her backing band as the Blue Moon Orchestra.