Mudhoney is an American rock band formed in Seattle, Washington, on January 1, 1988, following the demise of Green River. Its members are singer and rhythm guitarist Mark Arm, lead guitarist Steve Turner, bassist Guy Maddison and drummer Dan Peters. Original bassist Matt Lukin left the band in 1999, but rejoined the band in December 2000 for a tour that lasted through January 2001.

Mudhoney's early releases on the Sub Pop label, particularly their debut single "Touch Me I'm Sick" and the Superfuzz Bigmuff EP, were instrumental in the creation of the grunge genre. Although the band found little commercial success and remained somewhat 'underground' and non-mainstream, Mudhoney has released eleven studio albums and inspired countless grunge and alternative rock musicians during their long career.

Mudhoney's influences include Dinosaur Jr., Spacemen 3, Neil Young, the Stooges, Black Sabbath, Black Flag, and the Scientists.