MC5 was an American rock band formed in Lincoln Park, Michigan, in 1963. The classic line-up consisted of vocalist Rob Tyner, guitarists Wayne Kramer and Fred "Sonic" Smith, bassist Michael Davis, and drummer Dennis Thompson. MC5 were listed by Parade as one of the best rock bands of all time and by VH1 as one of the greatest hard rock artists of all time. The band's first three albums are regarded by many as staples of rock music, and their 1969 song "Kick Out the Jams" is widely covered.

"Crystallizing the counterculture movement at its most volatile and threatening", according to AllMusic critic Stephen Thomas Erlewine, MC5's leftist political ties and anti-establishment lyrics and music positioned them as emerging pioneers of the punk movement in the United States. Their loud, energetic style of back-to-basics rock and roll included elements of garage rock, hard rock, blues rock, and psychedelic rock. Rage Against the Machine guitarist Tom Morello described MC5 as having "basically invented punk rock."

MC5 had a promising beginning that earned them a January 1969 cover appearance on Rolling Stone and a story written by Eric Ehrmann before their debut live album was released. They developed a reputation for energetic and polemical live performances, one of which was recorded as their 1969 debut album Kick Out the Jams. The band released the albums Back in the USA and High Time before disbanding in 1972.

Vocalist Tyner died of a heart attack in late 1991 at the age of 46 and was followed by Fred Smith, who also died of a heart attack, in 1994 at the age of 46. The remaining three members of the band reformed in 2003 with The Dictators' singer Handsome Dick Manitoba as its new vocalist, and this reformed line-up occasionally performed live over the next nine years until Davis died of liver failure in 2012 at the age of 68.

In 2022, Kramer announced that a tour under the banner of We Are All MC5 would take place that spring, and that a new MC5 studio album with producer Bob Ezrin would also be released later that year with original MC5 drummer Dennis Thompson playing on two tracks. In 2023, Kramer announced that the album would be released in the spring of 2024. Kramer died February 2, 2024, leaving Thompson as the only surviving original member of the band. In 2024, the MC5 were selected for induction into the Rock and Roll Hall of Fame in the musical excellence category. On May 8, 2024, Thompson died at the age of 75. Heavy Lifting, the new studio album will be released on October 18, 2024.