The Mary Jane Girls were an American girl group formed in 1983, best known for their songs "In My House", "All Night Long", "Candy Man", and their cover version of "Walk Like a Man". They were protégées of musician Rick James and disbanded in 1987.

Joanne "Jojo" McDuffie was the lead singer, the others filling out the group's style and appearance. On the studio recordings, McDuffie was backed by session vocalists rather than the other Mary Jane Girls. The group released two albums in the 1980s, and recorded a third – which was shelved for decades but finally released in 2014 as part of a larger Rick James retrospective.

The group was inducted into the Rhythm & Blues Music Hall of Fame in 2019.