Jeffrey Scot Tweedy (born August 25, 1967) is an American musician, singer songwriter, author, and record producer best known as the lead vocalist and guitarist of the band Wilco. Tweedy, originally from Belleville, Illinois, began his music career in high school with his band The Plebes along with Jay Farrar, also in the band. It became the alternative country band Uncle Tupelo.

After Uncle Tupelo broke up Tweedy formed Wilco which found critical and commercial success, most notably with Yankee Hotel Foxtrot and A Ghost Is Born. The latter received a Grammy for Best Alternative Album in 2005.

During his career Tweedy has released 20 studio albums including four with Uncle Tupelo, twelve with Wilco, one with his son Spencer, a solo acoustic album, three solo studio albums, along with numerous collaborations with other musicians, most notably Mermaid Avenue with Billy Bragg.