James Franklin Murphy (born July 30, 1967) is an American guitarist. He is best known for his work in metal bands Cancer, Obituary, Death and Testament. He founded Disincarnate, an early death metal band.

He was diagnosed with a brain tumor in 2001 but recovered. In October 2011, Murphy stated that the tumor had returned but that it was non-cancerous and that it was being treated pharmacologically. He is working on a tribute album to Death founder Chuck Schuldiner who died from pneumonia, caused by complications of his treatment for a brain tumor. He also produced Deron Miller's band World Under Blood. He also completed production of the industrial death metal band Dååth's second album, The Hinderers, which was released on Roadrunner Records, and Lazarus A.D.'s first album The Onslaught, and its follow-up Black Rivers Flow released on Metal Blade Records,(Lazarus A.D. recorded a demo under the name Lazarus before adding the A.D., it was not released making The Onslaught the bands debut album) and many other productions and mixes on various record labels. He has also performed as a touring guitarist for Agent Steel in Europe and the UK in 1987, and was briefly in Hallows Eve in 1989.

In addition to playing guitar, Murphy operates a recording studio, SafeHouse Production, where he has mixed and produced albums for other bands. He has also contributed lessons to Guitar Player magazine.