Death of Samantha is an American rock band from Cleveland, Ohio, United States. Founded in 1983, the quartet debuted at a Ground Round family restaurant in Parma Heights. Death of Samantha played a farewell show on December 15, 1990, but later regrouped on December 23, 2012, with its original four-piece lineup: vocalist/guitarist John Petkovic, lead guitarist Doug Gillard, bassist David James and drummer Steven "Steve-O" Eierdam.

The band was signed by Gerard Cosloy to the New York-based Homestead Records. The band performed with contemporaries such as Sonic Youth, along with Nirvana, Jesus and Mary Chain, the Replacements, Smashing Pumpkins, the Gun Club, Leaving Trains and Redd Kross. Death of Samantha released three albums and an EP on Homestead from 1986 to 1990. Prior to signing, they released two critically acclaimed singles on local Ohio label St. Valentine Records.