Alien Crime Syndicate, often abbreviated to ACS, were a rock band formed in San Francisco, California, in 1997. From 1999 to the band's breakup in 2005, the lineup consisted primarily of Joe Reineke (vocals, guitar), Jeff Rouse (bass, backing vocals), Nabil Ayers (drums), while guitarists Jason Krevey, Mike Squires and Mike Davis were also members of the band.

Following the breakup of previous band The Meices, Joe Reineke formed Alien Crime Syndicate with Jeff Rouse in San Francisco, before they relocated to Los Angeles following a deal with Revolution Records. After recording their debut album, the label folded, with the band relocating to Seattle, adding Nabil Ayers, formerly of The Lemons, and Jason Krevey to the lineup. They released one EP in 1999 before releasing their debut album titled Dust to Dirt in 2001. Will Records then acquired the Revolution recorded album, titled From the Word Go, issuing it the same year.

By 2001, Jason Krevey departed the band and was replaced by former Nevada Bachelors guitarist Mike Squires. XL from Coast to Coast was released the following year, through Ayer's The Control Group label, with the album's first single "Ozzy" becoming a minor hit on local radio. The album was re-released, following a deal with V2 Records, while an EP titled Break the Record was released in 2003.

The band released their fourth and final album, titled Ten Songs in the Key of Betrayal, in 2004 through The Control Group, after leaving V2, with Mike Davis joining the band in place of Squires. A tour supporting Tommy Stinson followed, while they also performed as his backing band. However, by 2005, Alien Crime Syndicate disbanded with the members going on to various projects.