Alice in Chains (often abbreviated as AIC) is an American rock band formed in Seattle, Washington, in 1987. Since 2006, the band's lineup has comprised vocalist/guitarists Jerry Cantrell and William DuVall, bassist Mike Inez and drummer Sean Kinney. Vocalist Layne Staley and bassist Mike Starr are former members of the band, having died in 2002 and 2011, respectively. The band took its name from Staley's previous group, Alice N' Chains. Often associated with grunge music, Alice in Chains' sound and style is deeply rooted in heavy metal music. The band is known for its distinctive vocal style, which often included the harmonized vocals between Staley and Cantrell (and later Cantrell and DuVall), making Alice in Chains a two-vocal band.

Alice in Chains rose to international fame as part of the grunge movement of the early 1990s, along with other Seattle bands such as Nirvana, Pearl Jam, and Soundgarden. They achieved success during the era with the albums Facelift (1990), Dirt (1992) and Alice in Chains (1995), as well as the EP Jar of Flies (1994). The band was plagued by extended inactivity from 1996 onward, largely due to Staley's substance abuse, which resulted in his death in 2002 and caused the band to go on hiatus. Alice in Chains regrouped in 2005, with DuVall joining in 2006 as rhythm guitarist and later sharing lead vocal duties, and the band has since released three more albums: Black Gives Way to Blue (2009), The Devil Put Dinosaurs Here (2013) and Rainier Fog (2018).

Since its formation, Alice in Chains has released six studio albums, three EPs, three live albums, four compilations, two DVDs, 43 music videos and 32 singles. The band has sold more than 30 million records worldwide, and over 20 million records in the US alone. The band has had 18 Top 10 songs on Billboard's Mainstream Rock Tracks chart and 5 No. 1 hits, and has received eleven Grammy Award nominations. The band was ranked number 34 on VH1's 100 Greatest Artists of Hard Rock and as the 15th greatest live band by Hit Parader.