Destroy the Runner is an American melodic metalcore band from San Diego, California. The band released two full-length albums via Solid State Records prior to going on hiatus in 2010. In 2016 the band's original members reunited and independently released the band's latest effort Void.

The band is closely linked with fellow San Diego metal outfit As I Lay Dying. Both bands have shared members and personnel throughout their careers, and members from both bands have collaborated on various projects together. Additionally, As I Lay Dying vocalist Tim Lambesis managed Destroy the Runner for their albums Saints, and did so again with Jason Rudolph for their second album I, Lucifer.

Destroy the Runner are considered a Christian metal band.